Emerging Functions of IL-33 in Homeostasis and Immunity

• Published in: Annual review of immunology Vol. 40; no. 1; pp. 15 - 43
• Main Authors: Dwyer, Gaelen K, D'Cruz, Louise M, Turnquist, H th R
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 26-04-2022
• Subjects: Animals; Cytokines; damage-associated molecular patterns; Homeostasis; Humans; Hypersensitivity; IL-33; Immunity, Innate; Interleukin-33; Lymphocytes; tissue repair; type 2 immunity; homeostasis; cytokines; damage-associated molecular patterns; IL-33; type 2 immunity; tissue repair
• ISSN: 0732-0582; 1545-3278
• DOI: 10.1146/annurev-immunol-101320-124243

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2
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regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.