Cycloruthenated Primary and Secondary Amines as Efficient Catalyst Precursors for Asymmetric Transfer Hydrogenation

Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(η6-benzene)RuCl2]2 or with [(η6-p-cymene)RuCl2]2 are efficient catalysts for asymmetric transfer hydrogenation (TOF up to 190 h-1 at room temperature). Enantioselectivities in the transfer hydrogenat...

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Bibliographic Details
Published in:	Organic letters Vol. 7; no. 7; pp. 1247 - 1250
Main Authors:	Sortais, Jean-Baptiste, Ritleng, Vincent, Voelklin, Adeline, Holuigue, Alexandre, Smail, Hakima, Barloy, Laurent, Sirlin, Claude, Verzijl, Gerard K. M, Boogers, Jeroen A. F, de Vries, André H. M, de Vries, Johannes G, Pfeffer, Michel
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 31-03-2005
Subjects:	Chemical Sciences Coordination chemistry Ligands Amines Catalysts Aromatic compounds Transfer reactions
Online Access:	Get full text
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Summary:	Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(η6-benzene)RuCl2]2 or with [(η6-p-cymene)RuCl2]2 are efficient catalysts for asymmetric transfer hydrogenation (TOF up to 190 h-1 at room temperature). Enantioselectivities in the transfer hydrogenation of acetophenone ranged from 38% to 89%. It is possible to prepare the catalysts in situ, which allows the use of high throughput experimentation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol047353d