Spatially Addressable Multiprotein Nanoarrays Templated by Aptamer-Tagged DNA Nanoarchitectures

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings o...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 129; no. 34; pp. 10304 - 10305
Main Authors:	Chhabra, Rahul, Sharma, Jaswinder, Ke, Yonggang, Liu, Yan, Rinker, Sherri, Lindsay, Stuart, Yan, Hao
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 29-08-2007
Subjects:	Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - metabolism Humans Microscopy, Atomic Force Nanostructures - chemistry Nanostructures - ultrastructure Platelet-Derived Growth Factor - chemistry Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - ultrastructure Protein Array Analysis Thrombin - chemistry Thrombin - metabolism Thrombin - ultrastructure
Online Access:	Get full text
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Summary:	Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.
Bibliography:	ark:/67375/TPS-X8VRCV30-7 istex:4136ECF57D29CC4C791DAFA1167E90131C80FB83 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-7863 1272-7863 1520-5126
DOI:	10.1021/ja072410u