Mild and Highly Efficient Method for the Synthesis of 2-Arylbenzimidazoles and 2-Arylbenzothiazoles

• Published in: Journal of organic chemistry Vol. 73; no. 17; pp. 6835 - 6837
• Main Authors: Bahrami, Kiumars, Khodaei, M. Mehdi, Naali, Fardin
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 05-09-2008
• Subjects: Benzimidazoles - chemical synthesis; Benzothiazoles - chemical synthesis; Chemistry; Combinatorial Chemistry Techniques - methods; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Magnetic Resonance Spectroscopy; Models, Chemical; Organic chemistry; Preparations and properties; Sulfur nitrogen heterocycle; Chemoselectivity; Benzimidazole derivatives; Nitrogen heterocycle; Aromatic compound; Benzothiazole derivatives; Chemical synthesis
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo8010232

A new, convenient method for the syntheses of 2-substituted benzimidazole and benzothizole is described. Short reaction times, large-scale synthesis, easy and quick isolation of the products, excellent chemoselectivity, and excellent yields are the main advantages of this procedure.