Syntheses around the Transglycosylation Step in Peptidoglycan Biosynthesis

The problem of antibiotic resistance demands development of anti-infectives with novel modes of action. It is hoped that the present review demonstrates the transglycosylation reaction in peptidoglycan biosynthesis to be a promising target for new anti-infectives for a number of reasons.

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Bibliographic Details
Published in:	Chemical reviews Vol. 105; no. 12; pp. 4610 - 4660
Main Author:	Welzel, Peter
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-12-2005
Subjects:	Antibiotics Carbohydrate Conformation Carbohydrate Sequence Chemical synthesis Cyclization Drug resistance Glycosylation Molecular Sequence Data Molecular Structure Peptides Peptidoglycan - biosynthesis Peptidoglycan - chemistry Stereoisomerism Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives Uridine Diphosphate N-Acetylmuramic Acid - chemical synthesis Uridine Diphosphate N-Acetylmuramic Acid - chemistry
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Summary:	The problem of antibiotic resistance demands development of anti-infectives with novel modes of action. It is hoped that the present review demonstrates the transglycosylation reaction in peptidoglycan biosynthesis to be a promising target for new anti-infectives for a number of reasons.
Bibliography:	istex:1573AC83BB9A126B8B7C66FEA552612120BF5E17 ark:/67375/TPS-1P290KZS-W ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr040634e