Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats

• Published in: Behavioral neuroscience Vol. 107; no. 4; pp. 565 - 574
• Main Authors: Kelsey, John E, Vargas, Hannah
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychological Association 01-08-1993
• Subjects: Anatomical correlates of behavior; Animal; Animal memory; Animals; Behavioral psychophysiology; Biological and medical sciences; Brain; Brain Mapping; Discrimination Learning - physiology; Fundamental and applied biological sciences. Psychology; Hippocampus - physiology; Male; Mental Recall - physiology; Neural Pathways - physiology; Orientation - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Retention (Psychology) - physiology; Rodents; Septal Nuclei; Septal Nuclei - physiology; Septum Pellucidum - physiology; Short Term Memory; Spatial Memory; Rat; Rodentia; Central nervous system; Septum; Novelty stimulus; Learning; Vertebrata; Visual stimulus; Mammalia; Acquisition process; Animal; Lesion; Working memory; Spatial memory
• ISSN: 0735-7044; 1939-0084
• DOI: 10.1037/0735-7044.107.4.565

In Experiment 1, rats with small medial septal lesions were less able than were control rats to remember the location of the arm of a Y maze they had been forced to enter on the preceding sample run. Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonmatching-to-sample (DNMTS) task was increased to 1 and 2 min, the magnitude of the deficit increased. In contrast, these same lesioned rats were not deficient in Experiment 2 in their ability to remember the object they had encountered in the straight alley on the sample run. In fact, when the retention interval was increased to 1 min on this nonspatial DNMTS task, the rats with medial septal lesions were more accurate than were the controls. This pattern of results did not appear to be due to task difficulty, recovery of function, or sequence of training. Rather, these results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory.