Polyether Mimics of Naturally Occurring Cytotoxic Annonaceous Acetogenins

• Published in: Journal of medicinal chemistry Vol. 43; no. 12; pp. 2484 - 2487
• Main Authors: Yao, Zhu-Jun, Wu, Hai-Ping, Wu, Yu-Lin
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15-06-2000
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Drug Screening Assays, Antitumor; Furans - chemistry; General aspects; Humans; Lactones - chemistry; Medical sciences; Molecular Mimicry; Pharmacology. Drug treatments; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacology; Stereoisomerism; Tumor Cells, Cultured; Antineoplastic agent; Human; Triether; Ether; Aliphatic compound; Acetogenins; Leukemia; Furan derivatives; Cytotoxicity; Lactone; Oligomer; In vitro; Biological activity; HL60 cell line; Polyketides; Cell line; Biomimetic compound; Secondary alcohol; Chemical synthesis; Tumor cell
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm990575a

On the basis of the ionophore model, polyether analogues 4 and 6 were designed and synthesized to mimic the naturally occurring annonaceous acetogenins corossolin (2) and bullatin (5), which were discovered as members of a large family of novel polyketides with cytotoxicity, antitumoral, and other biological activities since 1982. The preliminary screening shows that they have compatible cytotoxicity with the corresponding natural annonaceous acetogenins. These results open a potential way to find more active antitumor agents with simplified structures based on natural annonaceous acetogenins.