A Statistical Thermodynamic Model of the Protein Ensemble

The background, physical basis, and the experimental validation of a structural thermodynamic model of the protein ensemble known as COREX is reviewed. The underpinnings of the COREX model are unique in that they were adopted for their simplicity.

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Bibliographic Details
Published in:	Chemical reviews Vol. 106; no. 5; pp. 1545 - 1558
Main Authors:	Hilser, Vincent J, García-Moreno E, Bertrand, Oas, Terrence G, Kapp, Greg, Whitten, Steven T
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-05-2006
Subjects:	Algorithms Kinetics Models, Chemical Models, Molecular Models, Statistical Molecular Structure Protein Conformation Proteins Proteins - chemistry Proteins - metabolism Structure-Activity Relationship Thermodynamics Validation studies
Online Access:	Get full text
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Description
Summary:	The background, physical basis, and the experimental validation of a structural thermodynamic model of the protein ensemble known as COREX is reviewed. The underpinnings of the COREX model are unique in that they were adopted for their simplicity.
Bibliography:	ark:/67375/TPS-K6H98H03-9 istex:38A79B6899C9A7E667E1D108658074FFF5781FA2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr040423+