Jerantinines A−G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa

• Published in: Journal of natural products (Washington, D.C.) Vol. 71; no. 9; pp. 1591 - 1594
• Main Authors: Lim, Kuan-Hon, Hiraku, Osamu, Komiyama, Kanki, Kam, Toh-Seok
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society and American Society of Pharmacognosy 01-09-2008; Glendale, AZ American Society of Pharmacognosy; American Chemical Society
• Subjects: anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Aspidosperma; Biological and medical sciences; chemical structure; cultured cells; cytotoxicity; Drug Screening Assays, Antitumor; General pharmacology; Humans; indole alkaloids; Indole Alkaloids - chemistry; Indole Alkaloids - isolation & purification; Indole Alkaloids - pharmacology; jerantinine; KB Cells; Malaysia; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plants, Medicinal - chemistry; spectral analysis; Tabernaemontana; Tabernaemontana - chemistry; Tabernaemontana corymbosa; Malaysia; Asia; Antineoplastic agent; Pentacyclic compound; Angular nitrogen heterocycle; Cytotoxicity; Medicinal plant; Apocynaceae; Ester; Alkaloid; Dicotyledones; Angiospermae; Aromatic compound; Tumor cell; Oxygen nitrogen heterocycle; Human; Pharmacognosy; Polycyclic compound; Epidermis; In vitro; Biological activity; Cell line; KB cell line; Epoxide; Plant origin; Phenols; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np800435c

Seven new indole alkaloids of the Aspidosperma type, jerantinines A−G (1−7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1−5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 μg/mL).