Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating...

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Bibliographic Details
Published in:Molecular pharmaceutics Vol. 11; no. 5; pp. 1721 - 1725
Main Authors: Charoenphol, Phapanin, Bermudez, Harry
Format: Journal Article
Language:English
Published: United States American Chemical Society 05-05-2014
Subjects:
Communication
DNA - chemistry
Drug Carriers - chemistry
Drug Delivery Systems
HeLa Cells
Humans
Nanomedicine
Nanostructures - chemistry
Oligodeoxyribonucleotides - chemistry
self-assembly
cancer therapy
nanomedicine
transfection
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Summary:DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibits the growth of cancer cells, achieved without the use of transfection reagents. Furthermore, aptamer-displaying pyramids are found to be substantially more resistant to nuclease degradation than single-stranded aptamers. These findings, along with their modularity, reinforce the potential of DNA-based nanostructures for therapeutic applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1543-8384
1543-8392
DOI:10.1021/mp500047b