Valved Sampling Cell for Membrane Introduction Mass Spectrometry

• Published in: Analytical chemistry (Washington) Vol. 68; no. 17; pp. 3072 - 3075
• Main Authors: LaPack, Mark A, Tou, James C, Cole, Mark J, Enke, Christie G
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-09-1996
• Subjects: Analytical chemistry; Chemistry; Exact sciences and technology; General, instrumentation; Instruments; Membranes; Scientific imaging; Sample cell; Response time; Instrumentation; Membrane; Valve; Injection; Mass spectrometry; Interface
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/ac9600870

Membrane extractors comprising a membrane house inside of a valve have been developed to separate compounds of interest from a sample matrix and introduce these compounds into a mass spectrometer. Experimental control over parameters that affect permeability or that may damage the membrane, such as the membrane temperature, is provided with the valve. The valve was tested for response and response times with the valve separated from the mass spectrometer by various interface tube lengths. Data for steady state response measurements showed no significant change with the valve at different distances from the ion source. Polar compounds show a strong response time dependency on the interface tube length. This adsorption phenomenon is minimized by simply heating the interface tube. Other factors affecting the performance of the device are discussed.