Stable and Inert Cobalt Catalysts for Highly Selective and Practical Hydrogenation of CN and CO Bonds

• Published in: Journal of the American Chemical Society Vol. 138; no. 28; pp. 8781 - 8788
• Main Authors: Chen, Feng, Topf, Christoph, Radnik, Jörg, Kreyenschulte, Carsten, Lund, Henrik, Schneider, Matthias, Surkus, Annette-Enrica, He, Lin, Junge, Kathrin, Beller, Matthias
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20-07-2016
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/jacs.6b03439

Novel heterogeneous cobalt-based catalysts have been prepared by pyrolysis of cobalt complexes with nitrogen ligands on different inorganic supports. The activity and selectivity of the resulting materials in the hydrogenation of nitriles and carbonyl compounds is strongly influenced by the modification of the support and the nitrogen-containing ligand. The optimal catalyst system ([Co­(OAc)2/Phen@α-Al2O3]-800 = Cat. E) allows for efficient reduction of both aromatic and aliphatic nitriles including industrially relevant dinitriles to primary amines under mild conditions. The generality and practicability of this system is further demonstrated in the hydrogenation of diverse aliphatic, aromatic, and heterocyclic ketones as well as aldehydes, which are readily reduced to the corresponding alcohols.