Electrochemical Cobalt-Catalyzed C–H Oxygenation at Room Temperature

Electrochemical Cobalt-Catalyzed C–H Oxygenation at Room Temperature

Electrochemical cobalt-catalyzed C–H functionalizations were achieved in terms of C–H oxygenation under mild conditions at 23 °C. The robust electrochemical C–H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C–H cleavage. The e...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 139; no. 51; pp. 18452 - 18455
Main Authors: Sauermann, Nicolas, Meyer, Tjark H, Tian, Cong, Ackermann, Lutz
Format: Journal Article
Language:English
Published: United States American Chemical Society 27-12-2017
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Summary:Electrochemical cobalt-catalyzed C–H functionalizations were achieved in terms of C–H oxygenation under mild conditions at 23 °C. The robust electrochemical C–H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C–H cleavage. The electrochemical cobalt-catalyzed C–H oxygenation proved viable on arenes and alkenes with excellent levels of positional and diastereo-selectivity, avoiding the use of stoichiometric silver­(I) oxidants under ambient conditions.
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content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.7b11025