Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

A stable and isolable difluoro­methyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoro­methylate aryl iodides, bromides, and triflates at room tempe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 138; no. 8; pp. 2536 - 2539
Main Authors: Xu, Long, Vicic, David A
Format: Journal Article
Language:English
Published: United States American Chemical Society 02-03-2016
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A stable and isolable difluoro­methyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoro­methylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoro­methylation of these substrates are unprecedented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.6b00053