MXenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges

• Published in: ACS biomaterials science & engineering Vol. 7; no. 6; pp. 1900 - 1913
• Main Authors: Iravani, Siavash, Varma, Rajender S
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14-06-2021
• Subjects: cancer therapy; nanosystems; biocompatibility; MXene-based composites; cancer diagnosis; drug delivery; MXenes
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.0c01763

MXenes endowed with several attractive physicochemical attributes, namely, specific large surface area, significant electrical conductivity, magnetism, low toxicity, luminescence, and high biocompatibility, have been considered as promising candidates for cancer therapy and theranostics. These two-dimensional (2D) nanostructures endowed with photothermal, chemotherapeutic synergistic, and photodynamic effects have shown promising potential for decidedly effectual and noninvasive anticancer treatments. They have been explored for photothermal/chemo-photothermal therapy (PTT) and for targeted anticancer drug delivery. Remarkably, MXenes with their unique optical properties have been employed for bioimaging and biosensing, and their excellent light-to-heat transition competence renders them an ideal biocompatible and decidedly proficient nanoscaled agent for PTT appliances. However, several important challenging issues still linger regarding their stability in physiological environments, sustained/controlled release of drugs, and biodegradability that need to be addressed. This Perspective emphasizes the latest advancements of MXenes and MXene-based materials in the domain of targeted cancer therapy/diagnosis, with a focus on the current trends, important challenges, and future perspectives.