Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae

Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae

Compared to other species of yeasts, the growth of Candida glabrata is inhibited by many different strains of killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high level...

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Published in:Antimicrobial agents and chemotherapy Vol. 65; no. 7; p. e0245020
Main Authors: Fredericks, Lance R, Lee, Mark D, Eckert, Hannah R, Li, Shunji, Shipley, Mason A, Roslund, Cooper R, Boikov, Dina A, Kizer, Emily A, Sobel, Jack D, Rowley, Paul A
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 17-06-2021
Subjects:
Antifungal Agents - pharmacology
Candida glabrata - genetics
Candidiasis, Vulvovaginal - drug therapy
Drug Resistance, Fungal - genetics
Experimental Therapeutics
Female
Humans
Ionophores
Microbial Sensitivity Tests
Saccharomyces cerevisiae - genetics
vulvovaginal
Candida glabrata
Saccharomyces
antifungals
candidiasis
killer toxins
polyene
azole
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Summary:Compared to other species of yeasts, the growth of Candida glabrata is inhibited by many different strains of killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.
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Hannah R. Eckert, Shunji Li, Mason A. Shipley, and Cooper R. Roslund contributed equally.
Citation Fredericks LR, Lee MD, Eckert HR, Li S, Shipley MA, Roslund CR, Boikov DA, Kizer EA, Sobel JD, Rowley PA. 2021. Vaginal isolates of Candida glabrata are uniquely susceptible to ionophoric killer toxins produced by Saccharomyces cerevisiae. Antimicrob Agents Chemother 65:e02450-20. https://doi.org/10.1128/AAC.02450-20.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02450-20