In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

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Published in:Antimicrobial Agents and Chemotherapy Vol. 17; no. 6; pp. 922 - 928
Main Authors: Van den Bossche, H, Willemsens, G, Cools, W, Cornelissen, F, Lauwers, W F, van Cutsem, J M
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 01-06-1980
Subjects:
Animals
Antifungal Agents
Antifungal Agents - pharmacology
Candida albicans
Candida albicans - drug effects
Candida albicans - growth & development
Candida albicans - metabolism
Cell Membrane - drug effects
Cholesterol - metabolism
Cholesterol - physiology
Culture Media
Dose-Response Relationship, Drug
Ergosterol
Ergosterol - biosynthesis
Female
Imidazoles
Imidazoles - pharmacology
Ketoconazole
Lanosterol - metabolism
Lanosterol - physiology
Piperazines
Piperazines - pharmacology
Rats
Research Article
Sterols - biosynthesis
Sterols - isolation & purification
Time Factors
Online Access:Get full text
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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList Ketoconazole, an orally active antimycotic drug, is a potent inhibitor of ergosterol biosynthesis in Candida albicans when added to culture media which support yeast or mycelial growth or to cultures containing outgrown mycelium. This inhibition coincides with accumulation of sterols with a methyl group at C-14 and can thus be attributed to an interference with one of the reactions involved in the removal of the 14 alpha-methyl group of lanosterol. When administered to rats infected with C. albicans, ketocanazole also inhibits fungal synthesis of ergosterol. A six-times-higher dose is required to effect cholesterol synthesis by rat liver.
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
Author J M van Cutsem
G Willemsens
W Cools
H Van den Bossche
F Cornelissen
W F Lauwers
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  fullname: Cornelissen, F
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  surname: Lauwers
  fullname: Lauwers, W F
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  givenname: J M
  surname: van Cutsem
  fullname: van Cutsem, J M
BackLink https://www.ncbi.nlm.nih.gov/pubmed/6250469$$D View this record in MEDLINE/PubMed
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Ketoconazole, an orally active antimycotic drug, is a potent inhibitor of ergosterol biosynthesis in Candida albicans when added to culture media which support...
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SubjectTerms Animals
Antifungal Agents
Antifungal Agents - pharmacology
Candida albicans
Candida albicans - drug effects
Candida albicans - growth & development
Candida albicans - metabolism
Cell Membrane - drug effects
Cholesterol - metabolism
Cholesterol - physiology
Culture Media
Dose-Response Relationship, Drug
Ergosterol
Ergosterol - biosynthesis
Female
Imidazoles
Imidazoles - pharmacology
Ketoconazole
Lanosterol - metabolism
Lanosterol - physiology
Piperazines
Piperazines - pharmacology
Rats
Research Article
Sterols - biosynthesis
Sterols - isolation & purification
Time Factors
Title In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis
URI http://aac.asm.org/content/17/6/922.abstract
https://www.ncbi.nlm.nih.gov/pubmed/6250469
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Volume 17
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