Efficient Multicomponent Active Template Synthesis of Catenanes

We describe a simple and high yielding active template synthesis of [2]catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocyclization of readily available bis-alkyne and bis-azide comonomer...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 140; no. 14; pp. 4787 - 4791
Main Authors:	Lewis, James E. M, Modicom, Florian, Goldup, Stephen M
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 11-04-2018
Subjects:	Communication
Online Access:	Get full text
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Summary:	We describe a simple and high yielding active template synthesis of [2]catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocyclization of readily available bis-alkyne and bis-azide comonomers and even short alkyne/azide components which oligomerize prior to mechanical bond formation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-7863 1520-5126
DOI:	10.1021/jacs.8b01602