The Methylation Effect in Medicinal Chemistry

Barreiro et al examine the impact methylation has in medicinal chemistry. Methyl groups are active with regard to metabolism.

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Bibliographic Details
Published in:	Chemical reviews Vol. 111; no. 9; pp. 5215 - 5246
Main Authors:	Barreiro, Eliezer J, Kümmerle, Arthur E, Fraga, Carlos A. M
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 14-09-2011
Subjects:	Amino Acids - chemistry Chemistry, Pharmaceutical - methods Drug Design Hydrophobic and Hydrophilic Interactions Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry Metabolism Methylation Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Stereoisomerism
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Description
Summary:	Barreiro et al examine the impact methylation has in medicinal chemistry. Methyl groups are active with regard to metabolism.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr200060g