Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin’s structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data...

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Bibliographic Details
Published in:Organic letters Vol. 21; no. 5; pp. 1453 - 1457
Main Authors: Sun, Changli, Yang, Zhijie, Zhang, Chunyan, Liu, Zhiyong, He, Jianqiao, Liu, Qing, Zhang, Tianyu, Ju, Jianhua, Ma, Junying
Format: Journal Article
Language:English
Published: United States American Chemical Society 01-03-2019
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Summary:Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin’s structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey’s method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 μM, respectively.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00208