Lewis Acid Mediated Trifluoromethylthio Lactonization/Lactamization
A highly selective Lewis acid mediated trifluoromethylthio lactonization/lactamization of olefins is described. The reaction was proposed to proceed via a thiiranium ion intermediate, which was further attacked by the carboxylic acid or amide to generate the corresponding trifluoromethylthiolated la...
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| Published in: | Organic letters Vol. 17; no. 18; pp. 4561 - 4563 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
American Chemical Society
18-09-2015
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| Online Access: | Get full text |
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| Summary: | A highly selective Lewis acid mediated trifluoromethylthio lactonization/lactamization of olefins is described. The reaction was proposed to proceed via a thiiranium ion intermediate, which was further attacked by the carboxylic acid or amide to generate the corresponding trifluoromethylthiolated lactone/lactam. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.5b02315 |