Asymmetric Total Synthesis of (+)-Strychnine

Asymmetric Total Synthesis of (+)-Strychnine

A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features of this synthesis include an organocatalytic enantioselective Michael addition to establish the chirality of the starting building block, a photoinduced radical cascade reaction to access t...

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Bibliographic Details
Published in:Organic letters Vol. 21; no. 1; pp. 252 - 255
Main Authors: He, Liping, Wang, Xiaobei, Wu, Xiaoqing, Meng, Zhaoxiang, Peng, Xin, Liu, Xiao-Yu, Qin, Yong
Format: Journal Article
Language:English
Published: United States American Chemical Society 04-01-2019
Online Access:Get full text
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Summary:A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features of this synthesis include an organocatalytic enantioselective Michael addition to establish the chirality of the starting building block, a photoinduced radical cascade reaction to access the Corynanthe alkaloid intermediate, and a bioinspired cascade rearrangement to generate the core of the Strychnos alkaloids.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03686