Ultra Magnetic Liposomes for MR Imaging, Targeting, and Hyperthermia

• Published in: Langmuir Vol. 28; no. 32; pp. 11834 - 11842
• Main Authors: Béalle, Gaëlle, Di Corato, Riccardo, Kolosnjaj-Tabi, Jelena, Dupuis, Vincent, Clément, Olivier, Gazeau, Florence, Wilhelm, Claire, Ménager, Christine
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 14-08-2012
• Subjects: Animals; Biological Transport; Chemistry; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Humans; Hyperthermia, Induced - methods; Liposomes; Magnetic Resonance Imaging - methods; Magnetite Nanoparticles - administration & dosage; MCF-7 Cells; Membranes; Mice; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Vesicle; Iron oxide; Volume fraction; Heating; Nanoparticle; Imaging; Preparation; Transition element compounds; Liposome; Mobility
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la3024716

Magnetic liposomes offer opportunities as theranostic systems. The prerequisite for efficient imaging, tissue targeting or hyperthermia is high magnetic load of these vesicles. Here we describe the preparation of Ultra Magnetic Liposomes (UMLs), which may encapsulate iron oxide nanoparticles in a volume fraction of up to 30%. This remarkable magnetic charge provides UMLs with high magnetic mobilities, MRI relaxivities, and heating capacities for magnetic hyperthermia. Moreover, these UMLs are rapidly and efficiently internalized by cultured tumor cells and, when they are administered to mice, they can be vectorized to tumors by an external magnet.