Catalytic Ynone–Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines

Catalytic Ynone–Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines

A Ca­(OTf)2- and self-promoted ynone–amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the...

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Bibliographic Details
Published in:Organic letters Vol. 22; no. 24; pp. 9653 - 9657
Main Authors: Reddy, T. Prabhakar, Gujral, Jagjeet, Roy, Pritam, Ramachary, Dhevalapally B
Format: Journal Article
Language:English
Published: United States American Chemical Society 18-12-2020
Online Access:Get full text
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Summary:A Ca­(OTf)2- and self-promoted ynone–amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03711