Sorting Technology for Circulating Tumor Cells Based on Microfluidics

• Published in: ACS combinatorial science Vol. 22; no. 12; pp. 701 - 711
• Main Authors: Hu, Dayu, Liu, He, Tian, Ye, Li, Zhi, Cui, Xiaoyu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14-12-2020
• Subjects: early diagnosis; microfluidic technology; circulating tumor cells; sorting methods
• ISSN: 2156-8952; 2156-8944
• DOI: 10.1021/acscombsci.0c00157

Circulating tumor cells (CTCs) carry reliable clinical information for the diagnosis and treatment of cancer that is a malignant disease with a high mortality rate. However, the amount of CTCs in the blood is quite low. To obtain credible clinical information, an efficient method of extracting CTCs is necessary. Microfluidic technology has proven its effectiveness on CTCs separation in recent years. Here, we present a comprehensive review of CTC sorting methods based on microfluidics. Specifically, we introduce four different microfluidic sorting methods of CTCs and compare their advantages and disadvantages. Finally, we summarize the analysis of CTCs based on microfluidics and present a prospective view of future research.