Complete Nucleotide Sequences of Two blaKPC-2-Bearing IncN Plasmids Isolated from Sequence Type 442 Klebsiella pneumoniae Clinical Strains Four Years Apart

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 5; pp. 2958 - 2960
• Main Authors: PEREZ-CHAPARRO, Paula Juliana, CERDEIRA, Louise Teixeira, TEIXEIRA NUNES, Marcio Roberto, MCCULLOCH, John Anthony, QUEIROZ, Maise Gomes, DE LIMA, Clayton Pereira Silva, LEVY, Carlos Emilio, PAVEZ, Mónica, LINCOPAN, Nilton, GONCALVES, Evonnildo Costa, MAMIZUKA, Elsa Masae, MELLO SAMPAIO, Jorge Luiz
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-05-2014
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; beta-Lactamases - genetics; Biological and medical sciences; Brazil; Drug Resistance, Multiple, Bacterial - genetics; Epidemiology and Surveillance; Klebsiella pneumoniae; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - genetics; Medical sciences; Pharmacology. Drug treatments; Plasmids; Plasmids - genetics; Brazil; Plasmid; Bacteria; Nucleotide sequence; Klebsiella pneumoniae; Enterobacteriaceae; Strain
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02341-13

We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005.