Cryptocaryol Structure–Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tolerant of large ster...

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Bibliographic Details
Published in:	ACS medicinal chemistry letters Vol. 5; no. 5; pp. 522 - 526
Main Authors:	Cuccarese, Michael F, Wang, Yanping, Beuning, Penny J, O’Doherty, George A
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 08-05-2014
Subjects:	Letter PDCD4 cryptocaryol SAR cryptocaryols PDCD4 stabilizer
Online Access:	Get full text
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Summary:	The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tolerant of large stereochemical changes to the molecule. Co-dosing studies with cryptocaryols A and B and several known cancer drugs showed no measuable enhancement in cancer drug cytotoxicity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1948-5875 1948-5875
DOI:	10.1021/ml4005039