Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

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Bibliographic Details
Published in:	ACS medicinal chemistry letters Vol. 5; no. 9; pp. 989 - 992
Main Authors:	Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 11-09-2014
Subjects:	Letter CSF1R receptor tyrosine kinases VEGF colony stimulating factor-1 receptor ras-mitogen activated protein kinase vascular endothelial growth factor receptor RTKs tyrosine kinases MAP serine threonine kinases TKs STKs
Online Access:	Get full text
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Description
Summary:	Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1948-5875 1948-5875
DOI:	10.1021/ml5002272