A Turn-On Fluorescent Sensor for Detecting Nickel in Living Cells

We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 131; no. 50; pp. 18020 - 18021
Main Authors:	Dodani, Sheel C, He, Qiwen, Chang, Christopher J
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 23-12-2009
Subjects:	Acetates - chemical synthesis Acetates - chemistry Boron Compounds - chemical synthesis Boron Compounds - chemistry Cell Culture Techniques Cell Line, Tumor Cell Survival Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Microscopy, Confocal Molecular Structure Nickel - analysis Spectrometry, Fluorescence
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Summary:	We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja906500m