Sea Cucumber Sterol Alleviates the Lipid Accumulation in High-Fat–Fructose Diet Fed Mice

• Published in: Journal of agricultural and food chemistry Vol. 68; no. 36; pp. 9707 - 9717
• Main Authors: Zeng, Bei-Bei, Zhang, Ling-Yu, Chen, Cheng, Zhang, Tian-Tian, Xue, Chang-Hu, Yanagita, Teruyoshi, Li, Zhao-Jie, Wang, Yu-Ming
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09-09-2020
• Subjects: Animals; Bioactive Constituents, Metabolites, and Functions; Body Weight - drug effects; Cholesterol - biosynthesis; Cucumaria - chemistry; Diet, High-Fat - adverse effects; Fatty Acids - metabolism; Fructose - adverse effects; Humans; Lipid Metabolism - drug effects; Liver - drug effects; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; Obesity - physiopathology; Sterols - administration & dosage; Sterols - chemistry; sea cucumber sterol; bile acid; lipid accumulation; cholesterol metabolism; sulfate group
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.0c03794

The effect of marine-derived sea cucumber sterol (SS) with a special sulfate group on lipid accumulation remains unknown, although phytosterol has been proved to have many biological activities, including lowering blood cholesterol. The purpose of the present study is to investigate the alleviation of SS on lipid accumulation and the possible underlying mechanism using high-fat–fructose diet fed mice. Dietary administration with SS for 8 weeks reduced significantly the body weight gain and lipid levels in serum and liver. Especially, SS was superior to phytosterol in lowering lipid accumulation due to the great promotion of fatty acid β-oxidation, the inhibition of cholesterol synthesis, and the acceleration of cholesterol efflux. The findings found that sea cucumber sterol exhibited a more significant effect than phytosterol on alleviating HFF-diet-induced lipid accumulation through regulating lipid and cholesterol metabolism, which might be attributed to the difference in the branch chain and sulfate group.