A Simple Conversion of Artemisinic Acid into Artemisinin

Artemisinic acid [1] has been converted into artemisinin [3] in 2 steps via reduction of the exocyclic methylene group and photooxidation of the resulting dihydroartemisinic acid [2].

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 52; no. 5; pp. 1183 - 1185
Main Authors:	Roth, Ronald J, Acton, Nancy
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-09-1989 Glendale, AZ American Society of Pharmacognosy
Subjects:	Antimalarials - chemical synthesis ARTEMISIA ARTEMISIA ANNUA Artemisinins Biological and medical sciences COMPOSICION COMPOSITION Drugs, Chinese Herbal - chemical synthesis General pharmacology Medical sciences Molecular Structure Oxidation-Reduction Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sesquiterpenes - chemical synthesis Temperature Antimalarial Chemical conversion Pharmacognosy Dicotyledones Angiospermae Spermatophyta Compositae Photooxidation Medicinal plant
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Description
Summary:	Artemisinic acid [1] has been converted into artemisinin [3] in 2 steps via reduction of the exocyclic methylene group and photooxidation of the resulting dihydroartemisinic acid [2].
Bibliography:	F60 9018646 ark:/67375/TPS-4ZBDVK2R-T istex:A03CC1D4EED7C1BBD42461701B4258030BDD8865 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50065a050