Constituents of the Leaves of Magnolia ovata

• Published in: Journal of natural products (Washington, D.C.) Vol. 72; no. 8; pp. 1529 - 1532
• Main Authors: Barros, Letícia Ferrari L, Barison, Andersson, Salvador, Marcos José, Mello-Silva, Renato de, Cabral, Elaine C, Eberlin, Marcos N, Stefanello, Maria Élida A
• Format: Journal Article
• Language: English
• Published: Northbrook, IL American Chemical Society and American Society of Pharmacognosy 28-08-2009; American Society of Pharmacognosy
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Biological and medical sciences; Brazil; Escherichia coli - drug effects; Flavonoids - isolation & purification; Flavonoids - pharmacology; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - pharmacology; General pharmacology; Glycosides - isolation & purification; Glycosides - pharmacology; Lignans - isolation & purification; Lignans - pharmacology; Magnolia; Magnolia - chemistry; Medical sciences; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plants, Medicinal - chemistry; Pseudomonas aeruginosa - drug effects; Staphylococcus aureus - drug effects; Staphylococcus epidermidis - drug effects; Yeasts - drug effects; Brazil; DPPH; Pharmacognosy; Plant leaf; Antioxidant; Naphthalene derivatives; Radical scavenger; Biological activity; Antimicrobial agent; Free radical; Medicinal plant; Dicotyledones; Magnoliaceae; Angiospermae; Plant origin; Isolation; Lignan; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np900203y

Two new lignans, magnovatins A (1) and B (2), along with nine known compounds, were isolated from the leaves of Magnolia ovata. The known compounds were identified as acuminatin (3), licarin A (4), kadsurenin M, 4-O-demethylkadsurenin M, oleiferin A, oleiferin C, spathulenol, parthenolide, and 11,13-dehydrocompressanolide. In addition, compounds 1 and 2 yielded four new derivatives (1a, 1b, 2a, and 2b). The structures of the new compounds were established on the basis of spectrometric data evaluation. Free-radical scavenging and antimicrobial activities of the major compunds 1, 3, and 4 were investigated.