Cochinolide, a New γ-Alkylidene Bicyclic Butenolide with Antiviral Activity, and Its β-Glucopyranoside from Homalium cochinchinensis

• Published in: Journal of natural products (Washington, D.C.) Vol. 61; no. 4; pp. 534 - 537
• Main Authors: Ishikawa, Tsutomu, Nishigaya, Kaori, Uchikoshi, Hide, Chen, Ih-Sheng
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-04-1998; Glendale, AZ American Society of Pharmacognosy
• Subjects: Acetylation; ANTIMICROBIAL PROPERTIES; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; ANTIVIRAL PROPERTIES; BARK; Biological and medical sciences; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CHEMISTRY; CHIMIE; Chromatography, Thin Layer; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CORTEZA; DRUG PLANTS; ECORCE; ESPECTROMETRIA; ESTRUCTURA QUIMICA; FLACOURTIACEAE; Furans - isolation & purification; Furans - pharmacology; General pharmacology; GLICOSIDOS; Glucosides - isolation & purification; Glucosides - pharmacology; GLYCOSIDE; GLYCOSIDES; Herpesvirus 1, Human - drug effects; HSV-1 VIRUSES; HSV-2 VIRUSES; LACTONAS; LACTONE; LACTONES; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Epidermis - chemistry; PLANTAS MEDICINALES; PLANTE MEDICINALE; Plants, Medicinal - chemistry; PROPIEDADES ANTIMICROBIANAS; PROPRIETE ANTIMICROBIENNE; QUIMICA; RACINE; RAICES; ROOTS; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; STEREOCHEMISTRY; STRUCTURE CHIMIQUE; TAIWAN; Asia; Taiwan; Alphaherpesvirinae; Bark; Alcohol; Oxygen heterocycle; Allylic compound; Medicinal plant; Herpesvirus hominis 1; Folk medicine; Herpesvirus hominis 2; Dicotyledones; Angiospermae; Flacourtiaceae; Bicyclic compound; Antiviral; Glycoside; Root; Pharmacognosy; Herpesviridae; Lactone; In vitro; Biological activity; Virus; Plant origin; Isolation; Spermatophyta; Benzofuran derivatives; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np970341z

A new γ-alkylidene bicyclic butenolide designated as cochinolide (1) and its β-glucopyranoside (3) were isolated from the root bark of Homalium cochinchinensis (Flacoutiaceae). Their structures, except absolute stereochemistries, were determined by spectroscopic means. Cochinolide (1) showed moderate antiviral activities against HSV-1 and -2.