Natural Product Synthesis via Palladium-Catalyzed Carbonylation

Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are...

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Bibliographic Details
Published in:	Journal of organic chemistry Vol. 82; no. 5; pp. 2319 - 2328
Main Authors:	Bai, Yu, Davis, Dexter C, Dai, Mingji
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 03-03-2017
Subjects:	Biological Products - chemical synthesis Biological Products - chemistry Catalysis Cyclization Ketones - chemistry Palladium - chemistry
Online Access:	Get full text
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Summary:	Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are presented in this Synopsis to highlight recent progress in this area, including our own work in macrolide and spirocyclic molecule synthesis. In these selected cases, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity and improving synthetic efficiency.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-3263 1520-6904
DOI:	10.1021/acs.joc.7b00009