Isohalitulin and Haliclorensins B and C, Three Marine Alkaloids from Haliclona tulearensis

• Published in: Journal of natural products (Washington, D.C.) Vol. 73; no. 3; pp. 456 - 458
• Main Authors: Sorek, Hagit, Rudi, Amira, Aknin, Maurice, Gaydou, Emile M, Kashman, Yoel
• Format: Journal Article
• Language: English
• Published: Northbrook, IL American Chemical Society and American Society of Pharmacognosy 26-03-2010; American Society of Pharmacognosy; American Chemical Society
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Artemia - drug effects; Biological and medical sciences; Chemical Sciences; Decapoda; General pharmacology; Haliclona; Haliclona - chemistry; Marine; Marine Biology; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Malagasy Republic; Africa; ISW, Madagascar, Tulear; Artemia salina; Pharmacognosy; Toxicity; Quinoline derivatives; Animal origin; Biological activity; Pyrrole derivatives; Macrocycle; Crustacea; Marine environment; Alkaloid; Porifera; Arthropoda; Isolation; Invertebrata; Branchiopoda; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np900500c

Three new alkaloids, designated isohalitulin (4), haliclorensin B (5), and haliclorensin C (6), were isolated from two specimens of the Madagascan sponge Haliclona tulearensis, collected at two locations in Salary Bay, north of Tulear. Their structures were elucidated by extensive spectroscopic means. Alkaloids 4−6 exhibited mild toxicity in the brine shrimp test.