Creating Organic Functional Materials beyond Chemical Bond Synthesis by Organic Cocrystal Engineering

• Published in: Journal of the American Chemical Society Vol. 143; no. 46; pp. 19243 - 19256
• Main Authors: Sun, Lingjie, Zhu, Weigang, Zhang, Xiaotao, Li, Liqiang, Dong, Huanli, Hu, Wenping
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24-11-2021
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/jacs.1c07678

Organic cocrystal engineering refers to two or more organic molecules stoichiometrically combined and held together by noncovalent intermolecular interactions, which differs from standard chemical synthesis involving covalent bond breakage and formation. Organic cocrystals have unique properties and offer a new strategy for creating enhanced organics. First, however, some key questions need to be addressed: How do diverse monomers affect the intermolecular interaction kinetics during cocrystallization? How do the intermolecular forces in cocrystals affect cocrystal functions? In this Perspective, the definition and advantages of organic cocrystal engineering, specifically in the construction of a reliable intermolecular interaction–stacking structure–performance relationship, are outlined. Additionally, recent developments in the field and the questions above are discussed. Finally, a brief conclusion and some hints on likely future developments are provided.