Continuous Synthesis of Carbamates from CO2 and Amines

• Published in: ACS omega Vol. 8; no. 50; pp. 48444 - 48450
• Main Authors: Stagel, Kristof, Ielo, Laura, Bica-Schröder, Katharina
• Format: Journal Article
• Language: English
• Published: American Chemical Society 19-12-2023
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.3c08248

We present a novel approach for the continuous preparation of carbamates. The simple yet fast synthetic route relies on directly utilizing carbon dioxide and, in contrast with the literature-known methods, only employs 1,8-diazabicyclo[5.4.0]­undec-7-ene as an additive. The applicable amines’ diversity offers considerable flexibility to the synthetic protocol. Additionally, the continuous method’s applicability significantly decreases the reaction time typically required for CO2-based carbamate synthesis and allows for straightforward and precise gas introduction. The mild reaction conditions and omission of the need for column chromatography render the process less time-demanding and environmentally more benign, providing the desired compounds in yields of 45 to 92%. Moreover, the modified procedure can potentially be applied in the selective synthesis of oxazolidinones from aziridines.