Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significa...

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Bibliographic Details
Published in:	The American journal of psychiatry Vol. 149; no. 11; p. 1592
Main Authors:	Renshaw, P F, Guimaraes, A R, Fava, M, Rosenbaum, J F, Pearlman, J D, Flood, J G, Puopolo, P R, Clancy, K, Gonzalez, R G
Format:	Journal Article
Language:	English
Published:	United States 01-11-1992
Subjects:	Adult Brain - metabolism Confidence Intervals Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - metabolism Female Fluorine Fluoxetine - analogs & derivatives Fluoxetine - blood Fluoxetine - metabolism Fluoxetine - therapeutic use Humans Magnetic Resonance Spectroscopy Male Obsessive-Compulsive Disorder - blood Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - metabolism
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Summary:	In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD = 1.0) (95% confidence interval = 1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
ISSN:	0002-953X
DOI:	10.1176/ajp.149.11.1592