Potent non-6-fluoro-substituted quinolone antibacterials: synthesis and biological activity

In this communication we describe the synthesis and biological activity of a series of 7-(aminopyrrolidinyl)-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinec arboxylic acids in which the fluorine atom is appended at C-5 or C-8 and then compare these compounds to known references and C-6 fluoro analogues...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 35; no. 1; pp. 198 - 200
Main Authors:	Ledoussal, Benoit, Bouzard, Daniel, Coroneos, Evangelos
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-01-1992
Subjects:	4-Quinolones Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Hydrocarbons, Fluorinated - chemical synthesis Hydrocarbons, Fluorinated - pharmacology Microbial Sensitivity Tests Structure-Activity Relationship
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In this communication we describe the synthesis and biological activity of a series of 7-(aminopyrrolidinyl)-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinec arboxylic acids in which the fluorine atom is appended at C-5 or C-8 and then compare these compounds to known references and C-6 fluoro analogues.
Bibliography:	istex:7BD0A64B99B63DD75C896ECC0090DAE191EAC745 ark:/67375/TPS-JNR924DW-N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00079a028