Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ‑Glutamyltransferase

We designed and synthesized an activatable near-infrared (NIR) fluorescent probe for γ-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in...

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Bibliographic Details
Published in:	Bioconjugate chemistry Vol. 29; no. 2; pp. 241 - 244
Main Authors:	Iwatate, Ryu J, Kamiya, Mako, Umezawa, Keitaro, Kashima, Hiroki, Nakadate, Mamiko, Kojima, Ryosuke, Urano, Yasuteru
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 21-02-2018
Subjects:	Animals Cell Line, Tumor Fluorescence Fluorescent Dyes - chemistry Fluorescent indicators gamma-Glutamyltransferase - analysis Humans I.R. radiation Mice Microscopy, Confocal - methods Neoplasms - enzymology Optical Imaging - methods Rhodamine Rhodamines - chemistry Silicon Silicon - chemistry Synthesis Tumors
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Summary:	We designed and synthesized an activatable near-infrared (NIR) fluorescent probe for γ-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in combination with previously reported probes, enables discrimination of tumors with different enzymatic profiles.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1043-1802 1520-4812
DOI:	10.1021/acs.bioconjchem.7b00776