High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 30; no. 6; pp. 959 - 961
Main Authors:	Gleason, John G, Hall, Ralph F, Perchonock, Carl D, Erhard, Karl F, Frazee, James S, Ku, Thomas W, Kondrad, Karen, McCarthy, Mary E, Mong, Seymour
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-06-1987
Subjects:	Animals Bronchi - drug effects Chemistry Dicarboxylic Acids - chemical synthesis Dicarboxylic Acids - pharmacology Exact sciences and technology Guinea Pigs Humans Muscle Contraction - drug effects Noncondensed benzenic compounds Organic chemistry Preparations and properties Receptors, Leukotriene Receptors, Prostaglandin - drug effects SRS-A - antagonists & inhibitors Structure-Activity Relationship Human Organic hydroxysulfide Aliphatic compound Rodentia Saturated compound In vitro Biological activity In vivo Vertebrata Mammalia Guinea pig Hydroxyacid Animal Absolute configuration Leucotriene D4 Benzenic compound Leukotriene antagonist
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Bibliography:	ark:/67375/TPS-JHDT7H70-R istex:F7CD05EEB21A9F74C527D9A9D03061062C352C31 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00389a001