Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)–N Bond Formation of Conjugated Tosyl Amides

Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)–N Bond Formation of Conjugated Tosyl Amides

A novel copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp2)–N bond formation with conjugated tosyl amides as starting materials is presented here. The reaction affords α-aryl-β-trifluoromethyl amides bearing a quaternary stereocenter or trifluoromethylated oxindol...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 135; no. 39; pp. 14480 - 14483
Main Authors: Kong, Wangqing, Casimiro, Maria, Merino, Estı́baliz, Nevado, Cristina
Format: Journal Article
Language:English
Published: United States American Chemical Society 02-10-2013
Subjects:
Amides - chemical synthesis
Amides - chemistry
Catalysis
Copper - chemistry
Halogenation
Indoles - chemical synthesis
Indoles - chemistry
Methylation
Stereoisomerism
Tosyl Compounds - chemical synthesis
Tosyl Compounds - chemistry
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Summary:A novel copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp2)–N bond formation with conjugated tosyl amides as starting materials is presented here. The reaction affords α-aryl-β-trifluoromethyl amides bearing a quaternary stereocenter or trifluoromethylated oxindoles in a regioselective manner.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja403954g