Diverse DNA-Cleaving Capacities of the Jadomycins through Precursor-Directed Biosynthesis

Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging propertie...

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Bibliographic Details
Published in:	Organic letters Vol. 12; no. 6; pp. 1172 - 1175
Main Authors:	Cottreau, Krista M, Spencer, Colin, Wentzell, Jason R, Graham, Cathy L, Borissow, Charles N, Jakeman, David L, McFarland, Sherri A
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 19-03-2010
Subjects:	DNA - chemistry DNA - drug effects DNA Cleavage DNA Damage Isoquinolines - chemistry Isoquinolines - metabolism Isoquinolines - pharmacology Molecular Structure Naphthoquinones - chemistry Naphthoquinones - metabolism Stereoisomerism Streptomyces - chemistry Streptomyces - metabolism Structure-Activity Relationship
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Summary:	Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol902907r