Direct Absorption of Acylated Anthocyanin in Purple-Fleshed Sweet Potato into Rats

• Published in: Journal of agricultural and food chemistry Vol. 50; no. 6; pp. 1672 - 1676
• Main Authors: Suda, Ikuo, Oki, Tomoyuki, Masuda, Mami, Nishiba, Yoichi, Furuta, Shu, Matsugano, Kazusato, Sugita, Koichi, Terahara, Norihiko
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13-03-2002
• Subjects: Absorption; Acylation; Animals; Anthocyanins - administration & dosage; Anthocyanins - blood; Anthocyanins - pharmacokinetics; Antioxidants - analysis; Benzopyrans - blood; Benzopyrans - pharmacokinetics; Biological and medical sciences; Chromatography, High Pressure Liquid; General pharmacology; Ipomoea batatas - chemistry; Kinetics; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rats; Rats, Wistar; Anthocyanin; Rat; Pharmacognosy; Rodentia; Oral administration; Acyl; Antioxidant; Convolvulaceae; Flavonoid; Biological activity; Blood plasma; In vivo; Vertebrata; Mammalia; Absorption; Dicotyledones; Angiospermae; Spermatophyta; Laboratory animal; Tuber plant; Ipomoea batatas
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf011162x

Absorption of acylated anthocyanins in purple-fleshed sweet potato (Ipomoea batatas cv. Ayamurasaki) in rats was studied to obtain evidence that the acylated anthocyanins themselves could exert a physiological function in vivo. Peonidin 3-caffeoylsophoroside-5-glucoside (Pn 3-Caf·sop-5-glc) in purple-fleshed sweet potato was directly absorbed into rat and present as an intact acylated form in plasma. After oral administration of the purple-fleshed sweet potato anthocyanin (PSA) concentrate containing 38.9 μmol of Pn 3-Caf·sop-5-glc/kg of body weight, Pn 3-Caf·sop-5-glc was detected in the plasma, and the C max value and t max were estimated as 50.0 ± 6.8 nmol/Lof plasma and 30 min, respectively. Furthermore, the plasma antioxidant capacity was significantly elevated from 58.0 ± 12.0 to 89.2 ± 6.8 μmol of Trolox equivalent/L of plasma 30 min after the administration of the PSA concentrate. Keywords: Anthocyanin; absorption; plasma antioxidant capacity; sweet potato