Preparation and Characterization of Decyl-Terminated Silicon Nanoparticles Encapsulated in Lipid Nanocapsules

• Published in: Langmuir Vol. 29; no. 41; pp. 12688 - 12696
• Main Authors: Pan, Guo-Hui, Barras, Alexandre, Boussekey, Luc, Qu, Xuesong, Addad, Ahmed, Boukherroub, Rabah
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15-10-2013
• Subjects: Chemical Sciences; Chemistry; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Hydrodynamics; Lipids - chemistry; Nanoparticles - chemistry; or physical chemistry; Particle Size; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Porosity; Silicon - chemistry; Surface Properties; Theoretical and; Characterization; Lipids; Nanocapsule; Silicon; Nanoparticle; Preparation; Particle size; Phosphotungstic acid; Silicon nanoparticles; Hydrosilylation; lipid; Nanoparticles; Uv-vis absorptions; Surface properties; Fourier transform infra red (ftir) spectroscopy; Negative staining; dynamic light scattering; Fluorescence imaging; nanocapsules; Surface property; hydrodynamics; Lipid nanocapsules; article; Chemistry; Transmission electron microscopy; Colloidal stability; Fourier transform infrared spectroscopy; Porosity; Porous silicon
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la4029468

In this Article, we report on the encapsulation of decyl-modified silicon nanoparticles (decyl-SiNPs) into ∼80 nm lipid nanocapsules (LNCs). The decyl-SiNPs were produced by thermal hydrosilylation of hydride-terminated SiNPs (H-SiNPs) liberated from porous silicon. Various techniques, including Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), UV–vis absorption, dynamic light scattering (DLS), and photoluminescence (PL), were used to characterize their size, shape, colloidal, and optical properties. The results indicate that these nanocapsules feature controllable size, good dispersity, high loading rate of SiNPs, colloidal stability in various media, and bright PL. The PL of decyl-SiNPs loaded LNCs was stable upon heating to 80 °C, but was sensitive to basic solutions due to proton-gated emission of the SiNPs arranged at the LNCs interface between the oil phase and the hydrophilic polyethylene glycol moieties of the surfactant. These luminescent nanocapsules are therefore promising candidates as cellular probes for fluorescence imaging. In addition, it was found that TEM imaging of small-sized decyl-SiNPs could be greatly improved by preliminary negative staining of TEM grids with phosphotungstic acid.