Spiro[1H-indene-1,4‘-piperidine] Derivatives As Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype 2 (sst2) Agonists

• Published in: Journal of medicinal chemistry Vol. 41; no. 13; pp. 2175 - 2179
• Main Authors: Yang, Lihu, Guo, Liangqin, Pasternak, Alexander, Mosley, Ralph, Rohrer, Susan, Birzin, Elizabeth, Foor, Forrest, Cheng, Kang, Schaeffer, James, Patchett, Arthur A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 18-06-1998
• Subjects: Animals; Biological and medical sciences; Cell Line; CHO Cells; Cricetinae; Cyclic AMP - agonists; Growth Hormone - secretion; Humans; In Vitro Techniques; Indoles - chemical synthesis; Indoles - chemistry; Indoles - metabolism; Indoles - pharmacology; Ligands; Medical sciences; Mice; Models, Molecular; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems; Pharmacology. Drug treatments; Piperidines - chemical synthesis; Piperidines - chemistry; Piperidines - metabolism; Piperidines - pharmacology; Pituitary Gland - cytology; Pituitary Gland - drug effects; Pituitary Gland - secretion; Rats; Receptors, Somatostatin - agonists; Receptors, Somatostatin - metabolism; Structure-Activity Relationship; Human; Agonist; Cyclohexane derivatives; Aminoamide; Peptide hormone; Non peptide compound; In vitro; Spiran; α-Aminoacid; Structure activity relation; Peptidergic receptor; Somatostatin; Chemical synthesis; Primary amine
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm980194h