Argenteanones C−E and Argenteanols B−E, Cytotoxic Cycloartanes from Aglaia argentea

• Published in: Journal of natural products (Washington, D.C.) Vol. 60; no. 2; pp. 81 - 85
• Main Authors: Mohamad, K, Martin, M.-T, Leroy, E, Tempête, C, Sévenet, T, Awang, K, Païs, M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-02-1997; Glendale, AZ American Society of Pharmacognosy
• Subjects: Antineoplastic Combined Chemotherapy Protocols - chemistry; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Biological and medical sciences; General pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Models, Molecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Saponins - chemistry; Saponins - pharmacology; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Stereoisomerism; Triterpenes; Tumor Cells, Cultured; Asia; Malaysia; Antineoplastic agent; Pentacyclic compound; Steroid; Furan derivatives; Medicinal plant; Acetal; Dicotyledones; Angiospermae; Established cell line; Tumor cell; Organic hydroperoxide; Pharmacognosy; Lactone; Plant leaf; Meliaceae; In vitro; Biological activity; Terpene; KB cell line; Plant origin; Triterpene; Isolation; Spermatophyta; Triol; Glycol; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np960594c

Seven new cycloartanes, argenteanones C−E (4−6) and argenteanols B−E (7−10), have been isolated from Aglaia argentea leaves. All of these compounds possess significant cytotoxic activity against KB cells (IC50 values between 3.7 and 6.2 μg/mL). Structure elucidation was performed by 2D NMR spectroscopy, aided by molecular modeling in the case of the side chain of compound 7.