Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane:  A New Positron Emission Tomography Ligand for Nicotinic Receptors

Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane:  A New Positron Emission Tomography Ligand for Nicotinic Receptors

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Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 40; no. 15; pp. 2293 - 2295
Main Authors: Liang, Feng, Navarro, Hernán A, Abraham, Philip, Kotian, Pravin, Ding, Yu-Shin, Fowler, Joanna, Volkow, Nora, Kuhar, Michael J, Carroll, F. Ivy
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 18-07-1997
Subjects:
Animals
Binding, Competitive
Biological and medical sciences
Brain - metabolism
Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Bridged Bicyclo Compounds, Heterocyclic - metabolism
Contrast media. Radiopharmaceuticals
Medical sciences
Mice
Nicotinic Antagonists - metabolism
Papio
Pharmacology. Drug treatments
Pyridines - chemical synthesis
Pyridines - chemistry
Pyridines - metabolism
Radioligand Assay
Receptors, Nicotinic - metabolism
Tomography, Emission-Computed
Rat
Nitrogen heterocycle
Exo stereoisomer
Rodentia
Central nervous system
In vitro
Precursor
Pyridine derivatives
Vertebrata
Alkaloid
Biological fixation
Cholinergic receptor
Mammalia
Scintigraphic agent
Animal
Chlorine Organic compounds
Bicyclic compound
Fluorine Organic compounds
Chemical synthesis
Nicotinic receptor
Brain (vertebrata)
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Bibliography:istex:D2270592DF5DB3821D36886A265E720ED3FEA73A
ark:/67375/TPS-75NBGF81-S
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm970187d