Electron Properties of Carbamazepine Drug in Form III

• Published in: Crystal growth & design Vol. 13; no. 7; pp. 2887 - 2896
• Main Authors: El Hassan, Nouha, Ikni, Aziza, Gillet, Jean-Michel, Spasojevic-de Biré, Anne, Ghermani, Nour Eddine
• Format: Journal Article
• Language: English
• Published: Washington,DC American Chemical Society 03-07-2013
• Subjects: Chemical Sciences; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Cristallography; Electron density of states and band structure of crystalline solids; Electron states; Exact sciences and technology; Life Sciences; Medication; Medicinal Chemistry; or physical chemistry; Pharmaceutical sciences; Physics; Polymers and organic compounds; Theoretical and; Drugs; Deformation; Electrostatic interaction; XRD; Topology; Carbamazepine; Electron density map; Quantum mechanics; Electron density; Electrostatics; Electrostatic potential; Interaction energy; Quantum theory; Atomic charge; Electrostatic force
• ISSN: 1528-7483; 1528-7505
• DOI: 10.1021/cg4002994

The experimental electron and electrostatic properties of carbamazepine drug molecule (form III) were determined from accurate high-resolution X-ray diffraction data collected at 100 K. The results are compared to quantum mechanics calculations for gas-phase molecule and multimers. The experimental electron density was refined using the Hansen–Coppens multipole formalism, and the deformation electron density maps are compared to the theoretical ones. Both experimental and theoretical deformation electron density maps presented here are based on Clementi’s promolecule densities used as a reference. The topological analysis of the carbamazepine electron density using Bader’s theory has been carried out, and the integrated atomic charges are presented and compared to those obtained for molecules with equivalent chemical fragments. The charge values compare qualitatively well with those obtained by theoretical calculations. The electrostatic potential features and the interaction electrostatic energies are also discussed.