Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

• Published in: ACS biomaterials science & engineering Vol. 8; no. 2; pp. 620 - 625
• Main Authors: Christensen, Thorbjørn Erik Køppen, Berglund Davidsen, Maiken, Van Malderen, Stijn, Garrevoet, Jan, Offermanns, Vincent, Andersen, Ole Zoffmann, Foss, Morten, Birkedal, Henrik
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14-02-2022
• Subjects: Animals; Bio-interactions and Biocompatibility; Calcium - pharmacology; Coated Materials, Biocompatible - pharmacology; Osseointegration; Rabbits; Strontium - pharmacology; Surface Properties; Titanium - pharmacology; strontium coating; bone formation; X-ray fluorescence; implant; synchrotron; osseointegration
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.1c01004

It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone–implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti–Sr–O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.